ARHGEF6 (C-term) Rabbit Polyclonal Antibody

CAT#: AP50239PU-N

ARHGEF6 (C-term) rabbit polyclonal antibody, Aff - Purified

Product Images

ARHGEF6 Antibody (C-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the ARHGEF6 antibody detected the ARHGEF6 protein (arrow).

Specifications

Product Data

• Applications: WB
• Recommended Dilution: ELISA: 1/1,000.
  Western blotting: 1/1,000.
• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 614-641 amino acids from the C-terminal region of human ARHGEF6
• Specificity: This antibody reacts to ARHGEF6.
• Formulation: PBS containing 0.09% (W/V) sodium azide as preservative
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Affinity chromatography on Protein A
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Rac/Cdc42 guanine nucleotide exchange factor 6
• Database Link:
  Entrez Gene 9459 Human
  UniProt ID Q15052
• Background: Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific mental retardation.
• Synonyms: COOL2, KIAA0006, PIXA, Alpha-Pix, COOL-2
• Note: Molecular Weight: Isoform2 71kd. 87499 Da

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Pancreatic cancer, Regulation of actin cytoskeleton