GFAP (K39) Rabbit Polyclonal Antibody

CAT#: AP32987SU-N

GFAP (K39) rabbit polyclonal antibody, Serum

Product Images

Immunofluorescence staining of a 9 days old Zebrafish embryo.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: Western blot.
  Immunofluorescence.
  Immunocytochemistry on permeabilized cells.
  Immunohistochemistry on Frozen Sections.
  Immunohistochemistry on Paraffin Sections.
  Recommended Dilutions: 1/100-1/200 for Immunohistochemistry with ABC as detection reagent, and 1/100-1/1000 for Immunoblotting applications.
• Reactivities: Human, Mouse, Rat, Zebrafish
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: GFAP preparation from Human spinal cord.
• Specificity: This antibody K39 reacts exclusively with Glial Fibrillary Acidic Protein which is present in astrocytes in the central nervous system and Schwann cells.
• Formulation: State: Serum
  State: Liquid Serum
  Preservative: 0.09% Sodium Azide
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Database Link:
  Entrez Gene 2670 Human
  UniProt ID P14136
• Background: GFAP (55 kD) is selectively located in astrocytes and represents the major constituent of astrocytic intermediate filaments. GFAP expression levels are highly variable during development of the central nervous system. In adults, GFAP levels increase as a result of the proliferation of astrocytes that occurs in a response to a variety of physical, chemical and etiological insults, including Alzheimer’s disease, epilepsy and multiple sclerosis.
  In the peripheral nervous system GFAP is expressed by Schwann cells. Upon differentiation, myelin forming Schwann cells down-regulate GFAP, whereas in non-myelin forming Schwann cells GFAP persists into adulthood.
• Synonyms: Glial Fibrillary Acidic Protein