Suppressor of Fused (SUFU) pSer342 Rabbit Polyclonal Antibody

CAT#: AP26040PU-S

Suppressor of Fused (SUFU) pSer342 rabbit polyclonal antibody, Aff - Purified

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western blot: 1:500 - 1:1000.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Peptide sequence around phosphorylation site of Serine 342 derived from Human Sufu
• Specificity: This antibody detects endogenous level of Sufu protein only when phosphorylated at serine 342.
• Formulation: Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
  State: Aff - Purified
  State: Liquid Ig fraction
• Concentration: lot specific
• Purification: Affinity-chromatography using epitope-specific peptide
• Conjugation: Unconjugated
• Storage: Store (in aliquots) at -20 °C. Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: SUFU negative regulator of hedgehog signaling
• Database Link:
  Entrez Gene 51684 Human
  UniProt ID Q9UMX1
• Background: SUFU encodes a component of the Sonic hedgehog (SHH; MIM 600725)/Patched (PTCH; MIM 601309) signaling pathway. Mutations in genes encoding components of this pathway are deleterious for normal development and are associated with cancer-predisposing syndromes (e.g., HPE3, MIM 142945; BCNS, MIM 109400; and GCPS, MIM 175700).
• Synonyms: Suppressor of fused homolog
• Note: Molecular weight: 54 kDa

Reference Data

• Protein Families: Druggable Genome, Transcription Factors
• Protein Pathways: Basal cell carcinoma, Hedgehog signaling pathway, Pathways in cancer