Nicotinic Acetylcholine Receptor alpha 7 (CHRNA7) (Internal) Goat Polyclonal Antibody

CAT#: AP22903PU-N

Nicotinic Acetylcholine Receptor alpha 7 (CHRNA7) (Internal) goat polyclonal antibody, Aff - Purified

Product Images

Human Brain, Cortex (formalin-fixed, paraffin-embedded) stained with CHRNA7 antibody followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Specifications

Product Data

• Applications: ELISA, IHC
• Recommended Dilution: ELISA.
  Immunohistochemistry on Paraffin Sections: 3 - 6 µg/ml.
• Reactivities: Human, Bovine, Canine, Chicken, Equine, Monkey, Porcine
• Host: Goat
• Clonality: Polyclonal
• Immunogen: Synthetic peptide from an internal region of human CHRNA7 (NP_000737.1)
• Specificity: This antibody reacts to Cholinergic Receptor, Nicotinic, Alpha Polypeptide 7 (CHRNA7).
  It also reacts with CHRNA7-FAM7A fusion isoform 1 (NP_647536.1) and isoform 2 (NP_683709.1).
• Formulation: Tris saline buffer, pH 7.3 containing 0.5% BSA as stabilizer and 0.02% sodium azide as preservative
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Immunoaffinity Chromatography
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens cholinergic receptor nicotinic alpha 7 subunit (CHRNA7), transcript variant 1
• Database Link:
  Entrez Gene 1139 Human
  UniProt ID P36544
• Background: The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region.
• Synonyms: Nicotinic acetylcholine receptor subunit alpha-7, CHRNA7, NACHRA7

Reference Data

• Protein Families: Druggable Genome, Ion Channels: Cys-loop Receptors, Transmembrane
• Protein Pathways: Calcium signaling pathway