SOX8 Rabbit Polyclonal Antibody

CAT#: AP20530PU-N

SOX8 rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analysis of Sox-8/9/17/18 antibody (Cat.-No.: AP20530PU-N) in extracts from COS7 cells.

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  Immunohistochemistry (IHC) analyzes of Sox-8/9/17/18 antibody (Cat.-No.: AP20530PU-N) in paraffin-embedded human brain tissue.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Western blot: 1/500 - 1/1000.
  Immunohistochemistry on paraffin sections: 1/50 - 1/200.
• Reactivities: Human, Mouse
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: This antibody detects endogenous levels of Sox-8/9/17/18 protein.
  (region surrounding Lys148)
• Formulation: Phosphate buffered saline (PBS), pH 7.2.
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.05% sodium azide
• Concentration: 1.0 mg/ml
• Purification: Affinity chromatography (> 95% (by SDS-PAGE)
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~ 47 kDa
• Gene Name: SRY-box 8
• Database Link:
  Entrez Gene 20681 MouseEntrez Gene 30812 Human
  UniProt ID P57073
• Background: Sox genes comprise a family of genes that are related to the mammalian sex determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. The highly complex group of Sox genes cluster at a minimum of 40 different loci that rapidly diverged in various animal lineages. At present 30 Sox genes have been identified, and members of this family have been shown to be conserved during evolution and to play key roles during animal development. Some are involved in human diseases, including sex reversal.
• Synonyms: SOX-8, SOX-9, SOX-17, SOX-18

Reference Data

• Protein Families: Transcription Factors