BACE2 (Center) Rabbit Polyclonal Antibody

CAT#: AP13084PU-N

BACE2 (Center) rabbit polyclonal antibody, Purified

Product Images

The anti-BACE2 Ctr Pab is used in Western blot to detect BACE2 in HL60 cell lysate.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: ELISA: 1/1,000.
  Western blot: 1/100 - 1/500.
• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the center region of human BACE2.
• Specificity: This antibody reacts to BACE2.
• Formulation: PBS with 0.09% (W/V) sodium azide
  State: Purified
  State: Liquid purified Ig
• Concentration: lot specific
• Purification: Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: beta-site APP-cleaving enzyme 2
• Database Link:
  Entrez Gene 25825 Human
  UniProt ID Q9Y5Z0
• Background: Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease and a frequent complication of Down syndrome. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein by 2 proteases, one of which is the protein encoded by BACE2. This gene localizes to the 'Down critical region' of chromosome 21. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease.
• Synonyms: Beta-secretase 2, AEPLC, ALP56, ASP21, Memapsin-1, Aspartic-like protease 56 kDa, Down region aspartic protease, ASP1