Jagged1 (JAG1) (110-125) Rabbit Polyclonal Antibody

CAT#: AP08812PU-N

Jagged1 (JAG1) (110-125) rabbit polyclonal antibody, Aff - Purified

Product Images

at 5 ug/ml, staining JAG1 in Formalin-Fixed, Paraffin-Embedded Human Kidney tissue by Immunohistochemistry.

Specifications

Product Data

• Applications: ELISA, IF, IHC, WB
• Recommended Dilution: ELISA: 1/2500 - 1/10000.
  Immunocytochemistry.
  Immunofluorescence: 1/100 - 1/500.
  Immunohistochemistry on Paraffin Sections: 5 µg/ml.
  Western Blot: 1/250 - 1/1000.
• Reactivities: Human, Chimpanzee, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to aa 110-125 of Human Jagged-1 protein.
• Specificity: Recognizes Human Jagged-1 (JAG1).
• Formulation: PBS, pH 7.2 containing 0.01% Sodium Azide as preservative.
  State: Aff - Purified
  State: Liquid purified Ig fraction.
• Concentration: lot specific
• Purification: Protein A Chromatography.
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: jagged 1
• Database Link:
  Entrez Gene 182 Human
  UniProt ID P78504
• Background: Jagged-1 (JAG1) is a cell surface protein which is one of several ligands that activate Notch and related receptors. JAG1 functions in an embryologically important signaling pathway and has also been shown to play a role in hematopoiesis. JAG1 inhibits proliferation of cd34+ macrophage progenitor cells and a JAG1 gene abnormality may be an aggravating factor in extrahepatic biliary atresia. Activation of NOTCH1 signaling by JAG1 induces monocyte-derived dendritic cell maturation in vitro. JAG1 interaction with NOTCH1 on tumor cells dramatically induces proliferation and inhibition of apoptosis in vitro. Either haploinsufficiency for wild-type JAG1 and/or dominant negative effects produced by mutated JAG1 are responsible for the Alagille syndrome.
• Synonyms: Jagged-1, hJ1, JAGL1
• Note: Predicted Molecular Weight: 134 kDa.