Nuclear Factor 1 (NFIA) Rabbit Polyclonal Antibody

CAT#: AP06720PU-N

Nuclear Factor 1 (NFIA) rabbit polyclonal antibody, Aff - Purified


USD 443.00

3 Weeks*

Size
    • 100 ug

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Specifications

Product Data
Applications ELISA, IHC, WB
Recommended Dilution Western blot: 1/500-1/1000.
Immunohistochemistry on paraffin sections: 1/50-1/200.
Reactivities Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen Synthetic peptide, corresponding to the amino acids 20-60 of Human NF-1A.
Specificity This antibody detects endogenous levels of NF-1 protein.
(region surrounding Gln34)
Formulation Phosphate buffered saline (PBS), pH 7.2.
State: Aff - Purified
State: Liquid purified Ig fraction
Preservative: 15 mM sodium azide
Concentration 1.0 mg/ml
Purification Affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE)
Conjugation Unconjugated
Storage Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Predicted Protein Size ~ 55 kDa
Gene Name Homo sapiens nuclear factor I/A (NFIA), transcript variant 1
Background NF-1, also designated CTF, consists of a family of CCAAT-box-binding proteins that stimulate DNA replication and activate transcription. Analysis of human NF-1 messenger RNA has revealed two forms of the NF-1 protein arising from an alternate splicing of a single NF-1 gene. NF-1 binds its consensus DNA element as a homodimer via an amino-terminal DNA-binding domain, and activates transcription through a putatively novel, proline-rich, carboxy-terminal transactivation domain. The NF-1 protein has been shown to recognize and bind the adenovirus type 2 promoter and activate transcription of herpes simplex virus thymidine kinase genes. The NF-1 consensus element has been found in the upstream promoter region of myriad eukaryotic genes, including that of Ha-Ras, α-globin, HSP 70, GRP 78, Histone H1,myelin basic protein and in the Xenopus laevis vitellogenin gene promoter.
Synonyms NFI-A, NF-I/A, CCAAT-box-binding transcription factor, TGGCA-binding protein, CTG
Reference Data
Protein Families Transcription Factors

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