SH3BP2 Sheep Polyclonal Antibody

CAT#: AP05082PU-N

SH3BP2 sheep polyclonal antibody, Purified

Product Images

Western blot analysis using anti-3BP2 at 10 ug/ml on recombinant full lenth 3BP2 protein (1), 3BP2 protein minus the PH domain (2), 3BP2 protein minus the PR domain (3) and 3BP2 protein minus the SH2 domain (4).

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western Blot: Detects a 85 kDa band in murine fibroblasts transfected with 3BP2.
• Reactivities: Mouse
• Host: Sheep
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Antibody developed using SH2 domain of the 3BP2 protein fused to GST.
• Specificity: This antibody reacts to 3BP2.
• Formulation: Phosphate buffered saline and 0.08% sodium azide
  State: Purified
  State: Liquid purified Ig
• Concentration: lot specific
• Conjugation: Unconjugated
• Storage: The antibody can be shipped at ambient temperature. Store (in aliquots) at -20°C only.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: SH3 domain binding protein 2
• Database Link:
  Entrez Gene 24055 Mouse
  UniProt ID P78314
• Background: 3BP2 (SH3 binding protein 2) was identified as a protein binding to the SH3 domain of the Abl proto-oncogene. Murine 3BP2 cDNA encodes a 559 amino acid protein of 85 kDa consisting of an N-terminal PH domain, a C-terminal SH2 domain and intervening proline-rich sequences. 3BP2 interacts via its Sh2 domain with Syk family protein tyrosine kinases Syk, Zap70, Grb2, Cbl, PLCg 1 and LAT in T lymphocytes and contributes to the transcriptional activation of NF-AT and AP-1. Mouse 3BP2 is 66% homologous to the human protein at the amino acid level.
• Synonyms: SH3 domain-binding protein 2, SH3BP-2, 3BP2, 3BP-2

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Natural killer cell mediated cytotoxicity