SPTBN1 Rabbit Polyclonal Antibody

CAT#: AP01504PU-N

SPTBN1 rabbit polyclonal antibody, Aff - Purified


USD 464.00

3 Weeks*

Size
    • 100 ug

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Specifications

Product Data
Applications WB
Recommended Dilution Western Blot: 1/500-1/1000.
Reactivities Human, Mouse
Host Rabbit
Clonality Polyclonal
Specificity Spectrin β II antibody detects endogenous levels of Spectrin β II protein. (region surrounding Met687)
Formulation Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
State: Aff - Purified
State: Liquid purified Ig fraction (>95% pure by SDS-PAGE)
Concentration 1.0 mg/ml
Purification Affinity chromatography
Conjugation Unconjugated
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Predicted Protein Size ~ 275 kDa
Background Spectrin is an actin binding protein that is a major component of the cytoskeletal superstructure of the erythrocyte plasma membrane. Spectrins function as membrane organizers and stabilizers by forming dimers, tetramers and higher polymers. Spectrin α I and spectrin β I are present in erythrocytes, whereas spectrin α II (also designated fodrin α) and spectrin β II (also designated fodrin β) are present in other somatic cells. The spectrin tetramers in erythrocytes act as barriers to lateral diffusion, but spectrin dimers seem to lack this function. Defects in the SPTB gene encoding spectrin β I are the cause of spherocytosis type I (SPH1), a disorder characterized by severe hemolytic anemia. Another disorder due to defects of SPTB is called elliptocytosis or elliptocytosis 3 (EL3). The human SPTB gene maps to chromosome 14q22-q23.2 and encodes the 2,137 amino acid, 246 kDa erythroid form of β-spectrin.
Synonyms SPTB2, Spectrin beta chain brain 1, Spectrin non-erythroid beta chain 1, Beta-II spectrin, Fodrin beta chain
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.