Somatostatin Receptor 1 (SSTR1) Rabbit Polyclonal Antibody

CAT#: AP01431PU-N

Somatostatin Receptor 1 (SSTR1) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analysis of SSTR1 antibody (Cat.-No.: AP01431PU-N) in extracts from COS-7 cells.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: Western Blot: 1/500-1/1000.
  Immunofluorescence: 1/50-1/200.
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide, corresponding to amino acids 20-70 of Human SSTR1
• Specificity: This antibody detects endogenous levels of SSTR1 protein. (region surrounding asn48)
• Formulation: PBS with 0.05% Sodium Azide, approx. pH 7.2.
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: 1.0 mg/ml
• Purification: Affinity-chromatography using epitope-specific immunogen
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~ 43 kDa
• Gene Name: somatostatin receptor 1
• Database Link:
  Entrez Gene 20605 MouseEntrez Gene 25033 RatEntrez Gene 6751 Human
  UniProt ID P30872
• Background: SSTRs (for somatostatin receptors) represent a family of G-protein-coupled receptors which mediate the diverse biological actions of somatostatin(SST). There are five distinct subtypes of SSTRs that bind two natural ligands, SST-14 and SST-28. SSTR2 gives rise to spliced variants, SSTR2A and 2B. SSTRs share common signaling pathways such as the ability to inhibit adenylyl cyclase via GTP binding proteins. Some of the subtypes are also coupled to tyrosine phosphatase (SSTR1,2), Ca2+ channels (SSTR2), Na+/H+ exchanger (SSTR1), PLA-2 (SSTR4), and MAP kinase (SSTR4). Individual target cells typically express more than one SSTR subtype and often all five isoforms. Subtypes of SSTR can form functional homo- and heterodimers.
• Synonyms: Somatostatin receptor type 1, SS-1-R, SS1-R, SS1R, SRIF-2

Reference Data

• Protein Families: Druggable Genome, GPCR, Transmembrane
• Protein Pathways: Neuroactive ligand-receptor interaction