ALDOB Rabbit Polyclonal Antibody
Other products for "ALDOB"
Specifications
Product Data | |
Applications | ELISA, IHC, WB |
Recommended Dilution | Western blot: 1/500-1/1000. Immunohistochemistry on paraffin sections: 1/50-1/200. |
Reactivities | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Specificity | This antibody detects endogenous levels of Aldolase B protein. (region surrounding Trp148) |
Formulation | Phosphate buffered saline (PBS), pH~7.2 with 0.05% Sodium Azide as preservative State: Aff - Purified State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE) |
Concentration | 1.0 mg/ml |
Purification | Affinity Chromatography using epitope-specific immunogen |
Conjugation | Unconjugated |
Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Predicted Protein Size | ~45 kDa |
Gene Name | aldolase, fructose-bisphosphate B |
Database Link | |
Background | Fructose 1,6-bisphosphate Aldolase catalyses the reversible condensation of glycerone-P and glyceraldehyde 3-phosphate into fructose 1,6-bisphosphate.Fructose 1,6-bisphosphate Aldolase exists as three forms, the muscle-specific Aldolase A, the liver-specific Aldolase B, and the brain-specific Aldolase C. Aldolase A, B, and C arose from a common ancestral gene, from which Aldolase B first diverged. Aldolase A is one of the most highly conserved enzymes known, with only about 2% of the residues changing per 100 million years. Aldolase B is regulated by the hormones insulin and glucagons and has been implicated in hereditary fructose intolerance disease. Aldolase C is 36 kDa polypeptide that is exclusively expressed in Purkinje cells. Aldolase C-positive Purkinje cells are organized in the cerebellum as stripes or bands that run from anterior to posterior across the cerebellum and alternate with bands of Aldolase C-negative Purkinje cells. |
Synonyms | Liver-type aldolase |
Reference Data |
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