CysLT2 (CYSLTR2) Rabbit Polyclonal Antibody

CAT#: AP01297PU-N

CysLT2 (CYSLTR2) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis with extracts from COLO cells using CYSLTR2 antibody.

Specifications

Product Data

• Applications: ELISA, IF, WB
• Recommended Dilution: Western blot: 1/500-1/1000.
  Immunofluorescence: 1/50-1/200.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide, corresponding to amino acids 292-343 of Human CysLTR2.
• Specificity: This antibody detects endogenous levels of CYSLTR2 protein (region surrrounding His324).
• Formulation: Phosphate buffered saline (PBS), pH 7.2
  State: Aff - Purified
  State: Liquid purifed Ig fraction
  Preservative: 0.05% Sodium azide
• Concentration: 1.0 mg/ml
• Purification: Affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~ 40 kDa
• Gene Name: cysteinyl leukotriene receptor 2
• Database Link:
  Entrez Gene 57105 Human
  UniProt ID Q9NS75
• Background: Cysteinyl leukotriene (CysLTs) induce intracellular calcium mobilization through the binding of two distinct seven-transmembrane, G protein-coupled receptors, designated CysLT1 Receptor and CysLT2 Receptor, to induce potent bronchoconstriction. Airway smooth muscle and macrophages express both receptor types, and additionally monocytes and eosinophils express CysLT1 Receptor, while cardiac Purkinje cells, adrenal medulla, peripheral blood leukocytes and brain also utilize CysLT2 Receptor. The effects of the CysLT Receptors can be blocked by antagonists, indicating a therapeutic mechanism for the treatment of asthma and allergies.
• Synonyms: Cysteinyl leukotriene receptor 2, CysLTR2, CYSLT2, HG57, HPN321, hGPCR21