Myeloperoxidase (MPO) Mouse Monoclonal Antibody [Clone ID: 266-6K1]

CAT#: AM32277PU-N

Myeloperoxidase (MPO) mouse monoclonal antibody, clone 266-6K1, Purified

Specifications

Product Data

• Clone Name: 266-6K1
• Applications: ELISA, IHC, IP, WB
• Recommended Dilution: Western Blot.
  Immunoassay.
  Immunoprecipitation.
  Immunohistochemistyr on frozen sections.
  The typical starting working dilution is 1/50.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Specificity:

  The monoclonal antibody 266-6K1 reacts with Myeloperoxidase (MPO), a glycoprotein with an alpha2beta2 heteromultimer expressed in all cells of the myeloid linage.

• Formulation: PBS
  State: Purified
  State: Liquid purified Ig fraction
  Stabilizer: 0,1% BSA
  Preservative: 0.02% sodium azide
• Concentration: lot specific
• Conjugation: Unconjugated
• Storage:

  Store the antibody undiluted at 2-8°C.

• Stability: Shelf life: one year from despatch.

• Gene Name: myeloperoxidase
• Database Link:
  Entrez Gene 4353 Human
  UniProt ID P05164
• Background:

  MPO is abundantly present in azurophilic granules of polymorphonuclear neutrophils. It is an important enzyme used during phagocytic lysis of engulfed foreign particles which takes part in the defence of the organism through production of hypochlorous acid (HOCl), a potent oxidant. MPO is rapidly released by activated polymorphonuclear neutrophils. Involvement of MPO has been described in numerous diseases such as atherosclerosis, lung cancer, Alzheimer's disease and multiple sclerosis. Autoimmune antibodies to MPO are involved in Wegeners disease. Since the discovery of MPO deficiency, initially regarded as rare and restricted to patients suffering from severe infections, MPO has more attracted clinical attention. In experimental studies antibodies to MPO can be used for various purposes ranging from flow cytometric analysis to detection of polymorphonuclear neutrophils in tissue sections.

• Synonyms: MPO