TLR2 Mouse Monoclonal Antibody [Clone ID: mTL2.7]

CAT#: AM32233PU-N

TLR2 mouse monoclonal antibody, clone mTL2.7, Purified

Specifications

Product Data

• Clone Name: mTL2.7
• Applications: ELISA, IHC, IP
• Recommended Dilution: Flow Cytometry.
  The typical starting working dilution is 1/50.
  Immunohistochemistry on frozen sections.
  Immunoassay.
  Immunoprecipitation.
• Reactivities: Mouse
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Specificity: Monoclonal antibody mT2.7 reacts with mouse Toll-like receptor 2 (TLR2).
  The monoclonal antibody mT2.7 stained overexpressed, as well as endogenous cell surface- and intercellular TLR2. The antibody does not affect cell activation through TLR2.
• Formulation: PBS
  State: Purified
  State: Liquid purified Ig fraction (0.2 µm filtered)
  Stabilizer: 0,1% BSA
  Preservative: 0.02% sodium azide
• Concentration: lot specific
• Conjugation: Unconjugated
• Storage:

  Store the antibody undiluted at 2-8°C.

• Stability: Shelf life: one year from despatch.

• Gene Name: toll like receptor 2
• Database Link:
  UniProt ID O60603
• Background:

  Toll-like receptors (TLR) are highly conserved throughout evolution and have been implicated in the innate defense to many pathogens. In Drosophila toll is required for the anti-fungal response, while the related 18-wheeler is involved in antibacterial defenses. In mammals, TLR identified as type I transmembrane signaling receptors with pattern recognition capabilities, have been implicated in the innate host defense to pathogens. TLR2 has been identified as a receptor that is central to the innate immune response to lipoproteins of Gram-negative bacteria, several whole Gram-positive bacteria, as well as a receptor for peptidoglycan and lipoteichoic acid and other bacterial cell membrane products. A functional interaction between TLR2 and TLR6 in the cellular response to various bacterial products has been discovered. The currently accepted paradigm regards TLR2 as an essential receptor for many eubacterial cell wall components, including lipoproteins and peptidoglycan. Bacterial species as diverse as mycobacteria, spirochetes, mycoplasma, Staphylococcus aureus, and Streptococcus pneumoniae have all been shown to mediate cellular activation via TLR2.

• Synonyms: Toll-like receptor 2