Lactoferrin (LTF) Mouse Monoclonal Antibody [Clone ID: 265-1K1]

CAT#: AM32106PU-N

Lactoferrin (LTF) mouse monoclonal antibody, clone 265-1K1, Liquid


USD 717.00

2 Weeks*

Size
    • 1 ml

Product Images

Specifications

Product Data
Clone Name 265-1K1
Applications ELISA, IHC, WB
Recommended Dilution Western Blotting. 
Immunohistochemistry on Frozens Sections. 
Recommended Dilutions: 1/50 (starting).
Reactivities Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Specificity The Monoclonal antibody 265-1K1 reacts with Human Lactoferrin (LF), an 80 kDa glycoprotein.
Formulation PBS
State: Liquid
State: Liquid 0.2 µm filtered
Stabilizer: 0.1% BSA
Preservative: 0.02% Sodium Azide
Concentration lot specific
Conjugation Unconjugated
Storage

Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.

Stability Shelf life: one year from despatch.

Gene Name lactotransferrin
Background

Lactoferrin was first isolated from human milk and plays an important part in the immune system and helps to fight infections. Lactoferrin promotes the health of the gastro-intestinal system by improving the intestinal microbial balance. In addition, LF can be found in epithelia and most body fluids and secretions. 
Lactoferrin is secreted in plasma by neutrophils. Its plasma concentration also represents a positive relation to the total pool of neutrophils and the rate of neutrophil turnover. In inflammation lactoferrin is released from secondary granules of neutrophilic leukocytes into the extracellular medium. Therefore the extracellular lactoferrin concentration can be used as an index for neutrophil activation. Lactoferrin strongly binds to iron and this iron binding property is considered to be an important antimicrobial. Human lactoferrin binds to bacterial products through its highly positively charged N-terminus, it kills various bacteria, most probably by inducing intracellular changes in these bacteria without affecting the membrane permeability. Cleavage by pepsin of lactoferrin leads to the release of lactoferricin H. This 47 amino acid peptide has more antimicrobial activity than its precursor and it can inhibit the classical but not the alternative complement pathway.
Lactoferrin also plays a role in signal transduction, immunomodulation and has antiadhesive, anticancer, antiviral activity.

Synonyms LTF, LF, Lactoferrin, EC=3.4.21, Talalactoferrin
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.