IL31 Mouse Monoclonal Antibody [Clone ID: B-S31]

CAT#: AM31280AF-N

IL31 mouse monoclonal antibody, clone B-S31, Azide Free

Specifications

Product Data

• Clone Name: B-S31
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Recombinant human IL-31
• Specificity: This antibody recognises both natural and recombinant IL-31.
• Formulation: Phosphate-buffered saline.
  Sterile-filtered through 0.22 µm.
  Carrier and preservative free
  State: Azide Free
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Ion exchange chromatography
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C.
• Stability: Shelf life: one year from despatch.
• Gene Name: interleukin 31
• Database Link:
  Entrez Gene 386653 Human
  UniProt ID Q6EBC2
• Background: Interleukin-31 (IL-31) is a recently discovered T-cell cytokine closely related to IL-6 type cytokines and is preferentially produced by T helper type 2 cells. IL-31 activity is mediated through the ligand-induced oligomerization of a dimeric receptor complex containing IL-31 receptor A and oncostatin M receptor. In response to IL-31 binding, these proteins activate the JAK/STAT and the AKT signaling pathways. RNA levels of IL-31 receptor A and oncostatin M receptor are induced in activated monocytes but are expressed constitutively in epithelial cells. IL-31, when overexpressed in transgenic mice, results in the development of pruritis, alopecia and skin lesions, and in humans may result in atopic dermatitis, suggesting that IL-31 may represent a novel target for antipruritic drug development.
• Synonyms: IL-31

Reference Data

• Protein Families: Secreted Protein, Transmembrane