CD2 Mouse Monoclonal Antibody [Clone ID: TS1/8]
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Specifications
Product Data | |
Clone Name | TS1/8 |
Applications | FC, FN |
Recommended Dilution | Flow cytometry. Functional application: Blocking. |
Reactivities | Human |
Host | Mouse |
Isotype | IgG1 |
Clonality | Monoclonal |
Immunogen | Cytotoxic T lymphocytes |
Specificity | This antibody recognizes CD2, a 50 kDa glycoprotein present on the human peripheral blood T lymphocytes and NK cells; also expressed by all thymocytes. |
Formulation | Phosphate buffered saline (PBS) State: Purified State: Liquid Ig fraction Preservative: 15 mM sodium azide, approx. pH 7.4 |
Concentration | lot specific |
Purification | Protein-A affinity chromatography |
Conjugation | Unconjugated |
Storage | Store undiluted at 2-8°C. DO NOT FREEZE! |
Stability | Shelf life: one year from despatch. |
Gene Name | CD2 molecule |
Database Link | |
Background | CD2 (also known as LFA-2) belongs to T lymphocyte glycoproteins of immunoglobulin superfamily. Its interaction with CD58 stabilizes adhesion between T cells and antigen presenting or target cells. Relatively low affinity of CD2 to CD58 (as measured in solution) is compensated within the two-dimensional cell-cell interface to provide tight adhesion. Moreover, T cell activation induces increased CD2 expression and its lateral mobility, making easier contact between CD2 and CD58. Subsequently, T cell activation causes fixation of CD58-CD2 at sites of cell-cell contact, thereby strengthening intercellular adhesion. CD2 deficiency reduces intestinal inflammation and helps to control infection. |
Synonyms | SRBC, Erythrocyte receptor, LFA-2, LFA-3 receptor, Rosette receptor |
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