c-Myc (MYC) Mouse Monoclonal Antibody [Clone ID: IMD-3]

CAT#: AM20611PU-N

c-Myc (MYC) mouse monoclonal antibody, clone IMD-3, Purified

Specifications

Product Data

• Clone Name: IMD-3
• Applications: IF, IHC, IP, WB
• Recommended Dilution: WB 0.1-0.5 ug/ml
  IHC-P 0.5-1 ug/ml
  ICC 1 ug/ml.
• Reactivities: Human, Mouse, Rat
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: Synthetic peptide corresponding to residues 408-439 of the Human p62c-Myc protein.
• Specificity: This antibody recognizes Human c-Myc.
• Formulation: 1.2% Sodium Acetate
  State: Purified
  State: Lyophilized purified Ig fraction
  Stabilizer: 2 mg BSA
  Preservative: 0.01 mg Sodium Azide
• Reconstitution Method: Restore with 1.2% Sodium Acetate or Neutral PBS
• Concentration: 0.1 mg/ml (after reconstitution with PBS)
• Purification: Affinity Chromatography
• Conjugation: Unconjugated
• Storage: Prior to reconstitution store at -20°C.
  Following reconstitution store undiluted at 2-8°C for one month
  or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: v-myc avian myelocytomatosis viral oncogene homolog
• Database Link:
  Entrez Gene 17869 MouseEntrez Gene 24577 RatEntrez Gene 4609 Human
  UniProt ID P01106
• Background: C-Myc is an oncogene that functions both in the stimulation of cell proliferation and in apoptosis. c-Myc elicits its oncogenic activity by causing immortalization, and to a lesser extent the transformation of cells,in addition to several other mechanisms. The c-MYC proto-oncogene encodes a transcription factor that is critical for cell growth and proliferation. It is one of the genes frequently altered in cancer cells in which it exhibits constitutive activity. Downregulation of c-Myc is critical for 2-Methoxyestradiol (2ME2)-induced oxidative stress and apoptosis in AML cells. And its up-regulation is important for promoting lymphocyte cell division, and demonstrating that GFP-c-Myc expression is a marker of proliferating lymphocytes in vivo.
• Synonyms: Transcription factor p64, BHLHE39

Reference Data

• Protein Families: Druggable Genome, Embryonic stem cells, Induced pluripotent stem cells, Stem cell - Pluripotency, Stem cell relevant signaling - JAK/STAT signaling pathway, Stem cell relevant signaling - TGFb/BMP signaling pathway, Stem cell relevant signaling - Wnt Signaling pathway, Transcription Factors
• Protein Pathways: Acute myeloid leukemia, Bladder cancer, Cell cycle, Chronic myeloid leukemia, Colorectal cancer, Endometrial cancer, ErbB signaling pathway, Jak-STAT signaling pathway, MAPK signaling pathway, Pathways in cancer, Small cell lung cancer, TGF-beta signaling pathway, Thyroid cancer, Wnt signaling pathway