CD40 Mouse Monoclonal Antibody [Clone ID: HB14]

CAT#: AM08347PU-N

CD40 mouse monoclonal antibody, clone HB14, Aff - Purified

Product Images

at 10 ug/ml staining CD40 in Human Tonsil by Immunohistochemistry, Formalin-Fixed Paraffin-Embedded tissue.

• 

  Human peripheral blood lymphocytes stained with purified HB14, followed by anti-mouse IgGs FITC

Specifications

Product Data

• Clone Name: HB14
• Applications: FC, IHC
• Recommended Dilution: Flow Cytometry: 0.5 µg/10E6 cells.
  Immunohistochemistry on Paraffin Sections: 10 µg/ml.
• Reactivities: Human, Monkey
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Human B cell line
• Specificity: This antibody recognizes TNFRSF5/CD40.
• Formulation: PBS, pH 7.2
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.09% Sodium Azide
• Concentration: lot specific
• Purification: Affinity Chromatography
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C.
• Stability: Shelf life: one year from despatch.
• Gene Name: CD40 molecule
• Database Link:
  Entrez Gene 958 Human
  UniProt ID P25942
• Background: CD40 (48 to 50 kDa) is a transmembrane glycoprotein mainly expressed on the surface of B cells and also expressed on monocytes, dendritic cells, and thymic epithelium. CD40 is a member of the tumor necrosis factor (TNF) receptor superfamily, which includes the low affinity nerve growth factor (NGF) receptor and CD95/Fas. CD40 is the receptor for CD40 ligand. CD40 ligand (CD40L, CD154, gp39, and TRAM) belongs to the TNF gene family and is expressed more widely than CD40 predominantly on activated CD4+ T cells. Following interaction with CD40 ligand, CD40 mediates a number of major immunoregulatory functions, central to the control of thymus dependent humoral immunity and may be critical in the development of cell mediated immune responses. Other biological actions include B cell homotypic adhesion, proliferation, immunoglobulin isotype switch, and secretion. Activation of CD40 has also been shown to inhibit the growth of certain B cell lymphomas and to induce the death of transformed cells of mesenchymal or epithelial origin.
• Synonyms: TNFRSF5, CDw40, Bp50