Troponin I fast skeletal muscle (TNNI2) Mouse Monoclonal Antibody [Clone ID: 2F12G2]
CAT#: AM06710PU-N
Troponin I fast skeletal muscle (TNNI2) mouse monoclonal antibody, clone 2F12G2, Purified
Other products for "TNNI2"
Specifications
Product Data | |
Clone Name | 2F12G2 |
Applications | ELISA, FC, IF, IHC, WB |
Recommended Dilution | Western Blot: 1/500-1/2000. Immunofluorescence: 1/200-1/1000. Flow Cytometry: 1/200-1/400. ELISA: 1/10000. Immunohistochemistry on Paraffin Sections: 10 µg/ml. |
Reactivities | Human |
Host | Mouse |
Isotype | IgG1 |
Clonality | Monoclonal |
Immunogen | Purified recombinant fragment of Human TNNI2 expressed in E. Coli. |
Specificity | This antibody recognizes Human TNNI2. Other species not tested. |
Formulation | PBS State: Purified State: Liquid purified antibody Stabilizer: 0.5% protein stabilizer Preservative: 0.05% Sodium Azide |
Concentration | lot specific |
Purification | Protein G Chromatography |
Conjugation | Unconjugated |
Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. |
Stability | Shelf life: one year from despatch. |
Predicted Protein Size | 21 kDa |
Database Link | |
Background | This gene encodes a fast-twitch skeletal muscle protein, a member of the troponin I gene family, and a component of the troponin complex including troponin T, troponin C and troponin I subunits. The troponin complex, along with tropomyosin, is responsible for the calcium-dependent regulation of striated muscle contraction. Mouse studies show that this component is also present in vascular smooth muscle and may play a role in regulation of smooth muscle function. In addition to muscle tissues, this protein is found in corneal epithelium, cartilage where it is an inhibitor of angiogenesis to inhibit tumor growth and metastasis, and mammary gland where it functions as a co-activator of estrogen receptor-related receptor alpha. This protein also suppresses tumor growth in human ovarian carcinoma. Mutations in this gene cause myopathy and distal arthrogryposis type 2B. Alternatively spliced transcript variants have been found for this gene. |
Synonyms | TNNI2 |
Reference Data |
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