alpha 1 Fetoprotein (AFP) Mouse Monoclonal Antibody [Clone ID: MBS-12]

CAT#: AM05441PU-S

alpha 1 Fetoprotein (AFP) mouse monoclonal antibody, clone MBS-12, Purified

Specifications

Product Data

• Clone Name: MBS-12
• Applications: ELISA, IHC
• Recommended Dilution: MBS-12 can be applied for detection of AFP on ELISAs and Immunohistochemistry on Frozen Sections.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Alpha-fetoprotein (AFP).
  Spleen cells from immunised BALB/c mice were fused with cells of the NS1 myeloma cell line.
• Specificity: This antibody clone MBS-12 specifically detects AFP, an important oncodevelopmental gene product, also expressed in adults during liver regeneration and hepatocarcinogenesis.
• Formulation: PBS
  State: Purified
  State: Liquid purified Ig fraction
  Preservative: 0.05% Sodium Azide
• Concentration: lot specific
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: alpha fetoprotein
• Database Link:
  Entrez Gene 174 Human
  UniProt ID P02771
• Background: Alpha Fetoprotein is a major plasma protein produced by the yolk sac and the liver during fetal life. alpha Fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha Fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha Fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. alpha Fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha Fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly.
• Synonyms: Alpha-1-fetoprotein, Alpha-fetoglobulin, HPAFP