Home Antibody All anti-ZNF521 antibodies
Also for ZNF521 (NM_015461)
|ZNF521 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human ZNF521.|
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1ug/ml, ICC: 2.5ug/ml, ELISA
|100 µg (1 mg/ml) in 1X PBS containing 1 mg/ml BSA, 50% glycerol and less than 0.02% sodium azide, pH 7.4.|
|Affinity chromatography purified via peptide column (Protein A or G Sepharose)
|Homo sapiens zinc finger protein 521 (ZNF521)|
|The zinc finger protein 521 (ZNF521) is a transcription factor containing an N-terminal transcriptional repressor motif and 30 zinc finger domains. It plays a role in both erythroid cell and osteoblast differentiation during development, inhibiting the activities of early B-cell factor 1 (EBF1) in erythroid cells and Runx2 in osteoblast precursors. ZFP521 binds to both Runx2 and histone deacetylase 3 (HDAC3), promotes their association and antagonizes Runx2 transcriptional activity in a HDAC3-dependent manner, thereby regulating osteoblast differentiation, skeletal development, and bone homeostasis.|
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Western blot analysis of ZNF521 in HeLa cell lysate with ZNF521 antibody at 1 µg/ml in (A) the absence and (B) the presence of blocking peptide.
Immunocytochemistry of HeLa cells with ZNF521 antibody at 2.5ug/ml.