Home Antibody All anti-ZNF350 antibodies
Also for ZNF350 (NM_021632)
|ZBRK1 antibody was raised against a 20 amino acid peptide near the carboxy terminus of the human ZBRK1.|
|Human, Mouse, Rat
||WB: 1 - 2 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens zinc finger protein 350 (ZNF350)|
Entrez Gene 59348 Human
|ZBRK1 is a member of the Kruppel-associated box-zinc finger protein (KRAB-ZFP) protein family of transcriptional repressors. ZBRK1 has been shown to not only be up-regulated in senescent fibroblasts but also interacts with BRCA1, a transcriptional regulator with tumor suppressor activity. ZBRK1 binds to a specific sequence within the GADD45 gene, supporting the assembly of a nuclear complex containing BRCA1 and repressing its transcription. Recent experiments demonstrate that ZBRK1 can homo-oligomerize in vitro and in vivo through a C-terminal transcriptional repression domain (CTRD), and this oligomerization facilitates the ZBRK1-directed transcriptional repression through ZBRK1 response elements. These results suggest that higher order ZBRK1 oligomers may assemble through both protein-DNA and CTRD-dependent protein-protein interactions.|
|Transcription Factors |
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Western blot analysis of ZBRK1 in A-20 lysate with ZBRK1 antibody at 1 µg/ml in (A) the absence and (B) the presence of blocking peptide.