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Anti-ZIC2 Antibody


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SKU Description Amount Price Availability*  
  • Rabbit polyclonal anti-ZIC-2 antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC416175) , 20ug Explanation
100ug 325 3-7 Days
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OriGene Data

ImmunogenThis affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding amino acids 189-206 of Mouse ZIC-2.
Clone Name IsotypeIgG
Species Reactivityhuman, chimpanzee, mouse, rat, dog Concentration1.0 mg/mL
Guaranteed Application *WB Suggested DilutionsELISA: 1:10,000 - 1:50,000, WB: 1:500 - 1:2,000
Buffer0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Note ZIC2 (also known as zinc finger protein of the cerebellum 2, HPE5, Zic family member 2 and odd-paired Drosophila homolog) is a nuclear protein that functions as a transcriptional repressor and may regulate tissue specific expression of dopamine receptor D1. In mouse, knockout of Zic1 leads to aplasia of cerebellum and skeletal abnormalities. Mutation in Zic2 and Zic3 in mouse and/or human cause holoprosencephaly and heterotaxis, respectively. Holoprosencephaly is the most common structural anomaly of the human brain.

Reference Data

Target NameHomo sapiens Zic family member 2 (ZIC2)
Alternative NameHPE5
Database LinkNP_009060
Entrez Gene 7546 Human
Entrez Gene 22772 Mouse
Entrez Gene 361096 Rat
Entrez Gene 485533 Dog
Related PathwayDruggable Genome Hedgehog signaling pathway

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* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot using Affinity Purified anti-ZIC2 antibody shows detection of a band ~55 kDa (arrowhead) corresponding to ZIC2 in lysates from (lane 1) mouse brain and (lane 2) rat brain. Approximately 20 ug of each lysate was run on a SDS-PAGE and transferred onto nitrocellulose followed by reaction with a 1:500 dilution of anti-ZIC2 antibody. Signal was detected using standard techniques. The upper band in the mouse brain lysate represents Zic2.


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