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Home Antibody All anti-ZC3H12A antibodies

Anti-ZC3H12A Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306953
  • Rabbit Polyclonal ZC3H12A Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC410904) , 20ug
100ug 325 In Stock
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WB(1)
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Also for ZC3H12A (NM_025079)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenZC3H12A antibody was raised against a 17 amino acid peptide near the center of human ZC3H12A .
Clone Name IsotypeIgG
Species ReactivityHuman Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB Suggested DilutionsWB: 1 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens zinc finger CCCH-type containing 12A (ZC3H12A)
Alternative NamedJ423B22.1; MCPIP; MCPIP1
Database LinkNP_079355
FunctionZC3H12A, also known as MCPIP, is an essential member of a family of novel CCCH-zinc finger proteins that regulate macrophage activation and may be involved in host immunity and inflammatory diseases. ZC3H12A has RNase activity that prevents some immune disorders by directly affecting the mRNA stability of interleukins such as IL-6 and IL12p40. Mice lacking the ZC3H12A gene suffered from severe anemia, and most dies within 12 weeks. Overexpression of ZC3H12A causes ER stress and induces a number of genes involved in apoptosis and autophagy, including JNK, PUMA, and beclin-1 in cardiac myoblasts, leading to cell death. ZC3H12A can also induce adipogenesis in 3T3-L1 pre-adipocytes in the absence of PPAPg, demonstrating the complex roles ZC3H12A plays.
Related Pathway

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WB Image
Western blot analysis of ZC3H12A in Raji cell lysate with ZC3H12A antibody at (A) 1 and (B) 2 µg/ml.

 

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