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Anti-ZBTB33 Antibody EPR4668
Also for ZBTB33 (NM_001184742)
|A synthetic peptide corresponding to residues in human Kaiso was used as an immunogen.|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
|Homo sapiens zinc finger and BTB domain containing 33 (ZBTB33), transcript variant 1|
Entrez Gene 10009 Human
Entrez Gene 56805 Mouse
Entrez Gene 501506 Rat
|Kaiso is a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus Kaiso-binding site TCCTGCNA. It contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target promoters. Kaiso may contribute to the repression of targets of the Wnt signaling pathway, and it may also activate transcription of a subset of targets by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-alpha (also known as karyopherin alpha2 or RAG cohort 1), which may mediate nuclear import of Kaiso (1).|
Wnt Signaling Pathway
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Western blot - Anti-Kaiso antibody [EPR4668]; All lanes : Anti-Kaiso antibody [EPR4668] at 1/1000 dilution.Lane 1 : Human heart lysate.Lane 2 : MCF7 lysate.Lane 3 : C6 lysate.Lane 4 : PC12 lysate.Lane 5 : NIH 3T3 lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled Goat anti Rabbit IgG at 1/2000 dilution.Predicted band size : 74 kDa.Observed band size : 95 kDa .