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Anti-ZAP70 Antibody E267
Also for ZAP70 (NM_001079)
|A synthetic peptide corresponding to residues in N-terminus of human ZAP-70 was used as immunogen.|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
||FC: 1:40; WB: 1:500; IP: 1:30
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Is unsuitable for ICC or IHC.
|Homo sapiens zeta-chain (TCR) associated protein kinase 70kDa (ZAP70), transcript variant 1|
|SRK; STCD; STD; TZK; ZAP-70|
Entrez Gene 7535 Human
Entrez Gene 22637 Mouse
Entrez Gene 301348 Rat
|This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq]. |
|Protein KinaseDruggable Genome Natural killer cell mediated cytotoxicityT cell receptor signaling pathwayPrimary immunodeficiency|
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Western blot - ZAP70 antibody [E267]; Anti-ZAP70 antibody [E267] at 1/500 dilution + Jurkat cell lysates.Predicted band size : 70 kDa.Observed band size : 70 kDa.