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Home Antibody All anti-YBX1 antibodies

Anti-YBX1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA322726
  • Anti-YBX1 Rabbit Polyclonal Antibody
100ul $325 2-3 Weeks
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IHC(2)
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Also for YBX1 (NM_004559)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenSynthetic peptide corresponding to a region derived from 310-324 amino acids of human Y box binding protein 1
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration0.5mg/ml
Guaranteed Application *IHC Suggested DilutionsELISA: 1:2000-5000, IHC: 1:25-100
BufferPBS pH7.3, 0.05% NaN3, 50% glycerol
Purification Antigen affinity purification

Reference Data

Target NameHomo sapiens Y box binding protein 1 (YBX1)
Alternative NameBP-8; CSDA2; CSDB; DBPB; MDR-NF1; NSEP-1; NSEP1; YB-1; YB1
Database LinkNP_004550
FunctionThis protein mediates pre-mRNA alternative splicing regulation. It binds to splice sites in pre-mRNA and regulates splice site selection and contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors. It can regulates the transcription of numerous genes. Its transcriptional activity on the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7'. Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'); such as MDR1 and HLA class II genes. Promotes separation of DNA strands that contain mismatches or are modified by cisplatin. Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA (in vitro).
Related Pathway

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IHC Image
Predicted cell location: Cytoplasm,Nucleus. Positive control: Human breast and renal cancer tissue . Recommended dilution: 1/25-100 The image on the left is immunohistochemistry of paraffin-embedded human breast cancer tissue using YBX1 antibody at dilution 1/15, on the right is treated with the synthetic peptide. (Original magnification:x 200)
IHC Image
Predicted cell location: Cytoplasm,Nucleus. Positive control: Human breast and renal cancer tissue . Recommended dilution: 1/25-100 The image on the left is immunohistochemistry of paraffin-embedded human renal cancer tissue using YBX1 antibody at dilution 1/15, on the right is treated with the synthetic peptide. (Original magnification:x200)

 

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