Home Antibody All anti-XBP1 antibodies
Also for XBP1 (NM_001079539)
|XBP-1 antibody was raised against a 18 amino acid peptide from near the amino terminus of human XBP-1.|
||ELISA, WB: 0.5 - 2 ug/ml, ICC: 10 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens X-box binding protein 1 (XBP1), transcript variant 2|
|TREB-5; TREB5; XBP-1; XBP2|
Entrez Gene 7494 Human
Entrez Gene 22433 Mouse
|X box binding protein 1 (XBP-1) is a key protein in the mammalian unfolded protein response (UPR) that protects the cell against the stress of malfolded proteins in the endoplasmic reticulum (ER) . Upon sensing unfolded proteins, an ER transmembrane endonuclease and kinase termed IRE1p is activated and excises an intron from XBP-1 mRNA. The spliced XBP-1 mRNA results in a 371 amino acid protein (XBP-1s) which is then translocated to the nucleus where it binds to the regulatory elements of downstream genes. Together with other UPR transcription factors such as ATF6, XBP-1 stimulates the production of ER stress proteins including the ER resident protein chaperones glucose regulated protein (GRP) 78 and GRP94 (3,4).|
|Transcription Factors |
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Western blot analysis of XBP-1 in HepG2 cell lysate with XBP-1 antibody at (A) 0.5, (B) 1 and (C) 2 ug/mL.
Immunocytochemistry of XBP-1 in HepG2 cells with XBP-1 antibody at 10 ug/mL.