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Home Antibody All anti-WWTR1 antibodies

Anti-WWTR1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA324034
  • Anti-WWTR1 Rabbit Polyclonal Antibody
100ul 325 2-3 Weeks
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WB(1)
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Also for WWTR1 (NM_001168278)
cDNA Clone shRNA/siRNA Lysate Protein Request Antibody

OriGene Data

ImmunogenPeptide sequence around aa.386~390 (V-E-S-A-L) derived from Human TAZ.
Clone Name IsotypeIgG
Species ReactivityHuman; Mouse; Rat Concentration1mg/ml
Guaranteed Application *WB Suggested DilutionsWB: 1:500-1000
Predicted MW Explanation 44kDa
BufferPBS pH7.3, 0.05% NaN3, 50% glycerol
Purification Antigen affinity purification

Reference Data

Target NameHomo sapiens WW domain containing transcription regulator 1 (WWTR1), transcript variant 2
Alternative NameTAZ
Database LinkNP_001161750
Entrez Gene 25937 Human
Entrez Gene 97064 Mouse
Entrez Gene 295062 Rat
FunctionTranscriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.
Related PathwayTranscription FactorsDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Predicted band size: 44 kDa . Positive control: Jurkat and Hela cells lysate. Recommended dilution: 1/ 500-1000. (Gel: 10%SDS-PAGE Lane1,2: Jurkat and Hela cells lysate Lysates: 30 ug per lane Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute)

 

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