Home Antibody All anti-WNT3 antibodies
Also for WNT3 (NM_030753)
|Peptide with sequence CGRGHNTRTEKRKEK, from the internal region of the protein sequence according to NP_110380.1.|
||ELISA: 1:16,000; WB: 1-3 ug/ml; IHC: 2-4 ug/ml
|Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.|
|Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
|In paraffin embedded Human Breast shows cytoplasm staining in some luminal epithelial cells
|Homo sapiens wingless-type MMTV integration site family, member 3 (WNT3)|
|The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 98% amino acid identity to mouse Wnt3 protein, and 84% to human WNT3A protein, another WNT gene product. The mouse studies show the requirement of Wnt3 in primary axis formation in the mouse. Studies of the gene expression suggest that this gene may play a key role in some cases of human breast, rectal, lung, and gastric cancer through activation of the WNT-beta-catenin-TCF signaling pathway. This gene is clustered with WNT15, another family member, in the chromosome 17q21 region. [provided by RefSeq]. |
Hedgehog signaling pathway
Wnt Signaling Pathway
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TA302636 (1µg/ml) staining of lysate of cell line HEK293 (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
TA302636 (2µg/ml) staining of paraffin embedded Human Breast. Steamed antigen retrieval with citrate buffer pH 6, HRP-staining.