Home Antibody All anti-WNT10A antibodies
Also for WNT10A (NM_025216)
|Wnt10a antibody was raised against a 14 amino acid peptide from near the carboxy terminus of human Wnt10a.|
|Human, Mouse, Rat
||WB: 1 - 2 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens wingless-type MMTV integration site family, member 10A (WNT10A)|
|OODD; SSPS; STHAG4|
Entrez Gene 80326 Human
Entrez Gene 22409 Mouse
Entrez Gene 316527 Rat
|Wnt10a is a member of the Wnt family, a gene family that encodes secreted signaling proteins that play crucial roles in normal development such as regulation of cell fate and patterning during embryogenesis as well as neoplastic transformation. Elevated levels of Wnt10a have been detected in several human tumors and cancer cell lines including colorectal cancer and chronic lymphocytic leukemia and it has been suggested that uncontrolled Wnt signaling may contribute to the defect in apoptosis that characterizes these malignancies. Recently, a mutation in Wnt10a was found to be associated with odonto-onycho-dermal dysplasia, an autosomal recessive ectodermal dysplasia. Despite the high homology of Wnt10a to Wnt10b, this Wnt10a antibody will not cross-react with Wnt10b.|
|Secreted ProteinTransmembrane Wnt signaling pathwayHedgehog signaling pathwayMelanogenesisPathways in cancerBasal cell carcinoma|
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Western blot analysis of Wnt10a in RAW264.7 cell lysate with Wnt10a antibody at (A) 1 and (B) 2 ug/ml.
Immunohistochemistry of Wnt10a in human skeletal muscle tissue cells with Wnt10a antibody at 10 ug/ml.