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Home Antibody All anti-WISP1 antibodies
UltraMAB

Anti-WISP1 GAT Antibody Polyclonal

Generated by Genomic Immunization

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA590295
  • Rabbit Polyclonal WISP1 Antibody
50ug 325 In Stock
This antibody qualifies for Season of Giving promotion: Earn $50 Amazon gift card (use promo code SPQ12081) or donation to Cancer.org (promo code SPQ12082) with $600 purchase of UltraMAB or TrueMAB. Click for details
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OriGene Data

ImmunogenDNA immunization. This antibody was made against a protein fragment from the C Terminus Region
Clone NamePolyclonal IsotypeIgG
Species ReactivityHuman Concentration1.12mg/ml
Guaranteed Application * Suggested DilutionsWB: 1:5000-1:20000; ELISA: 1:100-1:2000; IHC: 1:10-1:2000; IHC-P 1:250-1:2000
Buffer20 mM Potassium Phosphate, 150 mM Sodium Chloride, pH 7.0
Purification The fragment used for DNA immunization was expressed in E.coli and the purified protein fragment was used for affinity purification of the antibody.
Note This antibody was generated by SDIX's Genomic Antibody Technology ® (GAT). Learn about GAT

Reference Data

Target NameHomo sapiens WNT1 inducible signaling pathway protein 1 (WISP1), transcript variant 2
Alternative NameCCN4; WISP1c; WISP1i; WISP1tc
Database LinkNP_543028
Entrez Gene 8840 Human
FunctionThis gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq]
Related PathwayStem cell relevant signaling - DSL/Notch pathwayStem cell relevant signaling - Wnt Signaling pathwaySecreted ProteinES Cell Differentiation/IPSAdult stem cellsEmbryonic stem cellsDruggable Genome

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