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Home Antibody All anti-WAS antibodies

Anti-WAS Antibody EP2541Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA303736
  • Rabbit monoclonal antibody against WASP (EP2541Y )
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC424761) , 20ug
100ul 325 3-7 Days
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WB(1)
IHC(1)
FC(1)
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Also for WAS (NM_000377)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues near the C-terminus of human WASP was used as an immunogen.
Clone NameEP2541Y IsotypeTissue culture supernatant
Species ReactivityHuman ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC, FC Suggested DilutionsWB: 1:10000 - 1:50000; IHC-P: 1:100 - 1:250; ICC: 1:100 - 1:250; FC: 1:10 - 1:100
BufferDoes not react with Mouse, Rat. Is unsuitable for IP.
Purification PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for IP.

Reference Data

Target NameHomo sapiens Wiskott-Aldrich syndrome (WAS)
Alternative NameIMD2; SCNX; THC; THC1; WASP
Database LinkNP_000368
FunctionThe Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. Wiskott-Aldrich syndrome is a rare, inherited, X-linked, recessive disease characterized by immune dysregulation and microthrombocytopenia, and is caused by mutations in the WAS gene. The WAS gene product is a cytoplasmic protein, expressed exclusively in hematopoietic cells, which show signalling and cytoskeletal abnormalities in WAS patients. A transcript variant arising as a result of alternative promoter usage, and containing a different 5' UTR sequence, has been described, however, its full-length nature is not known. [provided by RefSeq].
Related Pathway
Adherens junction

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* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - WASP antibody [EP2541Y]; All lanes : Anti-WASP antibody [EP2541Y] at 1/50000 dilution.Lane 1 : TF-1 cell lysate.Lane 2 : U937 cell lysate.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 53 kDa.Observed band size : 60 kDa .
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - WASP antibody [EP2541Y]; TA303736 at 1/100 dilution staining WASP in paraffin-embedded human spleen tissue.
FC Image
Flow Cytometry - Anti-WASP antibody [EP2541Y]; Flow cytometry analysis of permeabilized U937 cells, staining WASP (red) with at 1/10 dilution. Rabbit IgG was used as negative control (green).

 

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