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Anti-VTN Antibody EP873Y
|A synthetic peptide corresponding to residues near the V10 subunit of human vitronectin was used as an immunogen.|
|Human, Mouse, Rat
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:2000 - 1:10000; IHC-P: Use at an assay dependent dilution; ICC/IF: 1:50 - 1:100
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant (Protein A or G Sepharose)
|Is unsuitable for Flow Cyt or IP.
|Homo sapiens vitronectin (VTN)|
|V75; VN; VNT|
|Vitronectin, a 75 kDa polypeptide along with a 10 kDa fragment, is a glycoprotein present on most cell surfaces, in extracellular fluids and plasma (1). Vitronectin promotes cellular adhesion and spreading, inhibits the membrane-damaging effect of the terminal cytolytic complement pathway and binds to several serpin serine protease inhibitors (2). As a member of the integrin family, Vitronectin contains the cell binding sequence arg gly asp (RGD), first found in fibronectin, and serves as a cell-to-substrate adhesion molecule (3). Vitronectin acts as an inhibitor of the complement cascade by binding to the C5b9 complex and it has also been shown to have has a novel and direct role in self-senescent-self intercellular recognition leading to macrophage phagocytosis of cells undergoing apoptosis (4). |
Senescence and Autophagy
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Western blot - Vitronectin antibody [EP873Y]; Anti-Vitronectin antibody [EP873Y] at 1/20000 dilution + Hu Serum membrane at 10 µg.Secondary.Goat anti-rabbit HRP labelled, at 1/2000 dilution.Observed band size : 75 kDa .
Immunohistochemistry (Paraffin-embedded sections) - Vitronectin antibody [EP873Y]; Ab45139 at a 1/100 dilution, staining human Vitronectin in human liver tissue by immunohistochemistry using paraffin embedded tissue.