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Anti-VTN Antibody EP781Y
|A synthetic peptide corresponding to residues near the hemopexin-like 1 domain of human Vitronectin was used as immunogen.|
|Human (Does not react with: Mouse, Rat)
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000; IP: 1:50; IHC-P: 1:100 - 1:250
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Does not react with Mouse, Rat
|Homo sapiens vitronectin (VTN)|
|V75; VN; VNT|
Entrez Gene 7448 Human
|Vitronectin also called serum spreading factor or complement S-protein, is a member of the pexin family (1). Found in serum and in tissues, Vitronectin exist in two forms; as a single chain (75kDa) and as a clipped form composed of two chains (65kDa and 10kDa). Vitronectin promotes cell adhesion, spreading and migration through specific interactions with cellular integrins, and inhibits cytolysis by the complement C5b-9 complex (2-4). Vitronectin also interacts with several critical proteins that regulate thrombosis and fibrinolysis. Vitronectin is phosphorylated by PKA and CKII (5). |
|Secreted ProteinDruggable Genome Focal adhesionECM-receptor interaction|
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Western blot - Vitronectin antibody [EP781Y]; Anti-Vitronectin antibody [EP781Y] at 1/20000 dilution + 10ug Human serum.Secondary.Goat anti-rabbit, HRP labelled. at 1/2000 dilution.Predicted band size : 54 kDa.Observed band size : 75 kDa .Additional bands at : 54 kDa (possible non-specific binding),60 kDa (possible non-specific binding).
Immunohistochemistry (Paraffin-embedded sections) - Vitronectin antibody [EP781Y]; This image shows human lung tissue treated with TA300649 at 1/100 dilution.