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Anti-VAV1 Antibody

* Buy one primary antibody, get 50% off a GAPDH loading control antibody.

WB(1)

IHC(1)

OriGene Data

Immunogen	Recombinant protein fragment contain a sequence corresponding to a region within amino acids 83 and 538 of Human VAV1
Clone Name		Isotype	IgG
Species Reactivity	Human	Concentration	0.33mg/ml
Guaranteed Application *	WB, IHC	Suggested Dilutions	WB:1:500-1:3000; IHC:1:100;
Buffer	0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Purification	Purified by antigen-affinity chromatography. (Protein A or G Sepharose)

Reference Data

Target Name	Homo sapiens vav 1 guanine nucleotide exchange factor (VAV1), transcript variant 1
Alternative Name	VAV
Database Link	NP_005419
Function	The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. [provided by RefSeq]
Related Pathway	EGFR1 Signaling Pathway Focal Adhesion Hemostasis Signaling by GPCR

Related Lysate from OriGene • Transient overexpression lysate of vav 1 guanine nucleotide exchange factor (VAV1) Anti-Tag Antibodies & WB Reagent • Anti-Tag Antibodies • Western Blot Reagent shRNA • VAV1 - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector • VAV1 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector • Vav1 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector • VAV1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector • Vav1 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector Related ORF Clones • Myc-DDK-tagged ORF clone of Homo sapiens vav 1 guanine nucleotide exchange factor (VAV1) as transfection-ready DNA • GFP-tagged ORF clone of Homo sapiens vav 1 guanine nucleotide exchange factor (VAV1) as transfection-ready DNA • Lenti ORF clone of Human vav 1 guanine nucleotide exchange factor (VAV1) , Myc-DDK-tagged • Lenti ORF clone of Human vav 1 guanine nucleotide exchange factor (VAV1), mGFP tagged Related cDNA Clones • Homo sapiens vav 1 guanine nucleotide exchange factor (VAV1) as transfection-ready DNA

Conjugation Services
OriGene provides conjugation services of TrueMAB antibodies with the following molecules:

• HRP
• Biotin
• PE
• FITC
• DyLight® 488
• DyLight® 550
• DyLight® 594
• DyLight® 633

* DyLight is a trademark of Thermo-Fisher Scientific

Bulk Order
OriGene offers bulk sizes of TrueMAB antibodies in both the BSA/glycerol formulation and the carrier-free (BSA/glycerol-free) formulation.

Contact us with your conjugation/bulk request: antibody@origene.com or 888-267-4436 (Tech Support)