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Also for VAV1 (NM_005428)
|Recombinant protein fragment contain a sequence corresponding to a region within amino acids 83 and 538 of Human VAV1|
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography. (Protein A or G Sepharose)
|Homo sapiens vav 1 guanine nucleotide exchange factor (VAV1), transcript variant 1|
|The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. [provided by RefSeq]|
EGFR1 Signaling Pathway
Signaling by GPCR
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Sample(30 ug of whole cell lysate) A:MOLT4 B:Raji (anti-VAV1 antibody diluted at 1:500)
Immunohistochemical analysis of paraffin-embedded serous OVCA, using VAV1(anti-VAV1 antibody) antibody at 1:100 dilution.