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Home Antibody All anti-USP28 antibodies

Anti-USP28 Antibody EPR4249(2)

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA310935
  • Rabbit Monoclonal antibody against USP28
  • FREE positive control: HEK293T cell transient overexpression lysate (LC412247) , 20ug
100ul 325 3-7 Days
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WB(1)
IF(1)
Assay(1)
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Also for USP28 (NM_020886)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human USP28 was used as an immunogen.
Clone NameEPR4249(2) IsotypeTissue culture supernatant
Species ReactivityHuman Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, ASSAY, IF Suggested DilutionsWB: 1:1000 - 1:10000; ICC/IF: 1:50 - 1:100
BufferDoes not react with Mouse, Rat. Is unsuitable for Flow Cyt,IHC-P or IP.
Purification pH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
Note Is unsuitable for Flow Cyt,IHC-P or IP.

Reference Data

Target NameHomo sapiens ubiquitin specific peptidase 28 (USP28)
Alternative NameKIAA1515
Database LinkNP_065937
FunctionThe ubiquitin-dependent protein degradation pathway is essential for proteolysis of intracellular proteins and peptides. Enzymes that remove ubiquitin from ubiquitin-conjugated peptides, like USP28, affect the fate and degradation of intracellular proteins and are essential for maintenance of cell-free ubiquitin pools (1). USP28 is a deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. It plays a role in DNA damage induced by apoptosis by specifically deubiquitinating proteins of the DNA damage pathway, such as CLSPN. USP28 is also involved in G2 DNA damage checkpoint by deubiquitinating CLSPN, thus preventing its degradation by the anaphase promoting complex/cyclosome (APC/C) (2).
Related Pathway

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WB Image
Western blot - Anti-USP28 antibody [EPR4249(2)]; All lanes : Anti-USP28 antibody [EPR4249(2)] at 1/1000 dilution.Lane 1 : 293T cell lysate.Lane 2 : HeLa cell lysate.Lane 3 : HT1376 cell lysate.Lane 4 : Human heart tissue lysate.Lane 5 : SW480 cell lysate.Lane 6 : A431 cell lysate.Lysates/proteins at 10 µg per lane.Secondary.Goat anti-Rabbit HRP at 1/2000 dilution.Predicted band size : 122 kDa.
Assay Image
Other-Anti-USP28 antibody [EPR4249(2)](TA310935); Equilibrium disassociation constant (KD)..
IF Image
Immunocytochemistry/ Immunofluorescence - Anti-USP28 antibody [EPR4249(2)]; TA310935 at 1/50 dilution staining USP28 in HeLa cells by Immunofluorescence.

 

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