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Anti-USP28 Antibody EPR4250(2)
Also for USP28 (NM_020886)
|A synthetic peptide corresponding to residues in human USP28 was used as an immunogen.|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
|Homo sapiens ubiquitin specific peptidase 28 (USP28), transcript variant 1|
Entrez Gene 57646 Human
Entrez Gene 235323 Mouse
Entrez Gene 315639 Rat
|The ubiquitin-dependent protein degradation pathway is essential for proteolysis of intracellular proteins and peptides. Enzymes that remove ubiquitin from ubiquitin-conjugated peptides, like USP28, affect the fate and degradation of intracellular proteins and are essential for maintenance of cell-free ubiquitin pools (1). USP28 is a deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. It plays a role in DNA damage induced by apoptosis by specifically deubiquitinating proteins of the DNA damage pathway, such as CLSPN. USP28 is also involved in G2 DNA damage checkpoint by deubiquitinating CLSPN, thus preventing its degradation by the anaphase promoting complex/cyclosome (APC/C) (2).|
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Western blot - USP28 antibody [EPR4250(2)]; All lanes : Anti-USP28 antibody [EPR4250(2)] at 1/1000 dilution.Lane 1 : 293T cell lysate.Lane 2 : SW480 cell lysate.Lane 3 : HeLa cell lysate.Lane 4 : A431 cell lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 122 kDa.