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Anti-UPF1 Antibody EPR4681

* Buy one primary antibody, get 50% off a GAPDH loading control antibody.

WB(1)

IHC(1)

OriGene Data

Immunogen	A synthetic peptide corresponding to residues in human RENT1 / hUPF1 was used as an immunogen.
Clone Name	EPR4681	Isotype	Rabbit IgG
Species Reactivity	Human, Mouse	Concentration
Guaranteed Application *	WB, IHC	Suggested Dilutions	FC: 1:10 - 100, ICC: 1:100 - 250, IHC: 1:100 - 250, IP: 1:10 - 100, WB: 1:10,000-50,000,
Buffer	Store at -20 C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Purification	(Protein A or G Sepharose)

Reference Data

Target Name	Homo sapiens UPF1 regulator of nonsense transcripts homolog (yeast) (UPF1)
Alternative Name	HUPF1; NORF1; pNORF1; RENT1; smg-2
Database Link	NP_002902
Function	RENT1 / hUPF1 is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. RENT1 / hUPF1 is located only in the cytoplasm. It interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for RENT1 / hUPF1.
Related Pathway

Related Lysate from OriGene • Transient overexpression lysate of UPF1 regulator of nonsense transcripts homolog (yeast) (UPF1) Anti-Tag Antibodies & WB Reagent • Anti-Tag Antibodies • Western Blot Reagent shRNA • UPF1 - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector • UPF1 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector • Upf1 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector • UPF1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector • Upf1 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector Related ORF Clones • Myc-DDK-tagged ORF clone of Homo sapiens UPF1 regulator of nonsense transcripts homolog (yeast) (UPF1) as transfection-ready DNA • Lenti ORF clone of Human UPF1 regulator of nonsense transcripts homolog (yeast) (UPF1), mGFP tagged • Lenti ORF clone of Human UPF1 regulator of nonsense transcripts homolog (yeast) (UPF1) , Myc-DDK-tagged • GFP-tagged ORF clone of Homo sapiens UPF1 regulator of nonsense transcripts homolog (yeast) (UPF1) as transfection-ready DNA Related cDNA Clones • Homo sapiens UPF1 regulator of nonsense transcripts homolog (yeast) (UPF1) as transfection-ready DNA • Homo sapiens UPF1 regulator of nonsense transcripts homolog (yeast) (UPF1) as transfection-ready DNA

Conjugation Services
OriGene provides conjugation services of TrueMAB antibodies with the following molecules:

• HRP
• Biotin
• PE
• FITC
• DyLight® 488
• DyLight® 550
• DyLight® 594
• DyLight® 633

* DyLight is a trademark of Thermo-Fisher Scientific

Bulk Order
OriGene offers bulk sizes of TrueMAB antibodies in both the BSA/glycerol formulation and the carrier-free (BSA/glycerol-free) formulation.

Contact us with your conjugation/bulk request: antibody@origene.com or 888-267-4436 (Tech Support)