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Home Antibody All anti-UNC93B1 antibodies

Anti-UNC93B1 Antibody

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SKU Description Amount Price Availability*  
TA306557
  • Rabbit Polyclonal Unc93b Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC410646) , 20ug Explanation
100ug 325 In Stock
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WB(1)
IHC(1)
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Also for UNC93B1 (NM_030930)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenUnc93b antibody was raised against a 19 amino acid peptide from near the amino terminus of human Unc93b.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 0.5 - 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens unc-93 homolog B1 (C. elegans) (UNC93B1)
Alternative NameIIAE1; Unc-93B1; UNC93; UNC93B
Database LinkNP_112192
Entrez Gene 81622 Human
Entrez Gene 54445 Mouse
Entrez Gene 361689 Rat
FunctionThe endoplasmic reticulum (ER) protein Unc93b, a human homolog of the C. elegans Unc93 gene, was initially identified by a forward genetic screen using N-ethyl-N-nitrosourea where a histidine-to-arginine substitution in Unc93b caused defects in Toll-like receptor (TLR) 3, 7 and 9 signaling. Unlike Unc93a, another homolog of the C. elegans Unc93 gene whose function is unknown, Unc93b specifically interacts with TLR3, 7 and 9; the histidine-to-arginine point mutation used to identify Unc93b abolishes this interaction. Mice carrying this point mutation are highly susceptible to infection with a number of viruses, indicating that Unc93b plays an important role in innate immunity. Multiple isoforms of Unc93a are known to exist. This antibody will not cross-react with Unc93a.
Related PathwayTransmembrane

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of Unc93b in human heart tissue lysate with Unc93b antibody at (A) 0.5 and (B) 1 ug/ml.
IHC Image
Immunohistochemistry of Unc93b in human heart with Unc93b antibody at 2.5 ug/ml.

 

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