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Home Antibody All anti-UNC13B antibodies

Anti-UNC13B Antibody


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SKU Description Amount Price Availability*  
TA308991 Rabbit Polyclonal antibody to UNC13B (unc-13 homolog B (C. elegans)) 100ul $325 3-7 Days
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OriGene Data

ImmunogenRecombinant fragment corresponding to a region within amino acids 462 and 749 of UNC13B (Uniprot ID#O14795)
Clone Name IsotypeIgG
Species ReactivityHuman (Predicted: Mouse, Rat, Bovine) Concentration1mg/ml
Guaranteed Application *WB, IHC Suggested DilutionsIHC:1:100-1:1000; WB:1:1000-1:10000
Predicted MW Explanation 181kDa
Buffer0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Purification Purified by antigen-affinity chromatography.
Note Seq homology of immunogen across species: Mouse (98%), Rat (98%), Bovine (97%)

Reference Data

Target NameHomo sapiens unc-13 homolog B (C. elegans) (UNC13B)
Alternative NameMUNC13; UNC13; Unc13h2
Database LinkNP_006368
Entrez Gene 10497 Human
Entrez Gene 22249 Mouse
Entrez Gene 64830 Rat
FunctionThis gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis. [provided by RefSeq]
Related PathwayDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Sample (30 ug of whole cell lysate). A: Hela. 5% SDS PAGE. TA308991 diluted at 1:5000.

IHC Image
Immunohistochemical analysis of paraffin-embedded MCF7 xenograft, using UNC13B(TA308991) antibody at 1:500 dilution.


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