Home Antibody All anti-UNC13B antibodies
Also for UNC13B (NM_006377)
|Recombinant fragment corresponding to a region within amino acids 680 and 957 of UNC13B (Uniprot ID#O14795)|
|Human (Predicted: Mouse, Rat, Bovine)
|WB, IHC, IF
||ICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:500-1:3000
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography.
|Seq homology of immunogen across species: Mouse (99%), Rat (98%), Bovine (99%)
|Homo sapiens unc-13 homolog B (C. elegans) (UNC13B)|
|MUNC13; UNC13; Unc13h2|
Entrez Gene 10497 Human
Entrez Gene 22249 Mouse
Entrez Gene 64830 Rat
|This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis. [provided by RefSeq]|
|Druggable Genome |
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Sample (30 ug of whole cell lysate). A: 293T. 5% SDS PAGE. TA308990 diluted at 1:500.
Immunohistochemical analysis of paraffin-embedded A549 xenograft, using UNC13B(TA308990) antibody at 1:500 dilution.
Confocal immunofluorescence analysis (Olympus FV10i) of methanol-fixed HeLa, using UNC13B(TA308990) antibody (Green) at 1:500 dilution. Alpha-tubulin filaments were labeled with anti-alpha tubulin antibody (Red) at 1:2000.