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Home Antibody UltraMAB

UltraMAB

TOP2A UltraMAB Antibody, Clone UMAB145

UltraMAB™ Antibodies - Validated with 10K Protein Chip

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Specifications Citations (0) Related Products Product Documents
SKU Description Datasheet Price Availability*  
UM800042
  • TOP2A mouse monoclonal antibody,clone UMAB145, 100 ul
$468 In Stock Add to Shopping Cart
UM870042
  • TOP2A mouse monoclonal antibody,clone UMAB145, 30 ul
$120 In Stock Add to Shopping Cart
CE marked antibody of this clone also available.
IHC(3)
Data Img
IF(1)
Data Img

OriGene Data

ImmunogenHuman recombinant protein fragment corresponding to amino acids 1100-1531 of human TOP2A(NP_001058) produced in E.coli.
Clone NameClone UMAB145 IsotypeIgG1
Species ReactivityHuman Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *IHC, IF Suggested Dilutions IHC 1:200,
BufferPBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens topoisomerase (DNA) II alpha 170kDa (TOP2A)
Alternative NameTOP2; TP2A
Database LinkNP_001058
FunctionThis gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq, Jul
Related Pathway

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* OriGene provides validated application data and protocol, with money back guarantee.

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-TOP2A mouse monoclonal antibody. (UM800042; heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH9.0, 120C for 3min)
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Immunohistochemical staining of paraffin-embedded Human colon tissue using anti-TOP2A mouse monoclonal antibody. (UM800042; heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH9.0, 120C for 3min)
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Immunohistochemical staining of paraffin-embedded Human lymphoma tissue using anti-TOP2A mouse monoclonal antibody. (UM800042; heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH9.0, 120C for 3min)
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Immunofluorescent staining of HeLa cells using anti-TOP2A mouse monoclonal antibody (UM800042, green, 1:100). Actin filaments were labeled with Alexa Fluor® 594 Phalloidin (red), and nuclear with DAPI (blue).
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