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Home Antibody UltraMAB

UltraMAB

MUC1/EMA UltraMAB Antibody, Clone UMAB57

UltraMAB™ Antibodies - Validated with 10K Protein Chip

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Specifications Citations (0) Related Products Product Documents
SKU Description Datasheet Price Availability*  
UM800008
  • MUC1/EMA mouse monoclonal antibody,clone UMAB57, 100 ul
$468 In Stock Add to Shopping Cart
UM870008
  • MUC1 mouse monoclonal antibody,clone UMAB57, 30 ul
$120 In Stock Add to Shopping Cart
IHC(8)
Data Img
IF(1)
Data Img
10K-CHIP(1)
Data Img
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Also for MUC1/EMA (NM_001018016)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenFull length human recombinant protein of human MUC1 (NP_001018016) produced in HEK293T cell.
Clone NameClone UMAB57 IsotypeIgG2b
Species ReactivityHuman Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *IHC, IF, 10K-CHIP Suggested Dilutions IHC 1:100,
BufferPBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens mucin 1, cell surface associated (MUC1), transcript variant 2
Alternative NameADMCKD; ADMCKD1; CA 15-3; CD227; EMA; H23AG; KL-6; MAM6; MCD; MCKD; MCKD1; MUC-1; MUC-1/SEC;
Database LinkNP_001018016
FunctionThis gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011].
Related Pathway

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* OriGene provides validated application data and protocol, with money back guarantee.

Immunohistochemical staining of paraffin-embedded Human normal breast tissue and breast adenocarcinoma tissue using anti-MUC1 mouse monoclonal antibody. (UM800008; heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.0, 120C for 3min)
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Immunohistochemical staining of paraffin-embedded Human normal colon tissue and colorectal cancer tissue using anti-MUC1 mouse monoclonal antibody. (UM800008; heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.0, 120C for 3min)
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Immunohistochemical staining of paraffin-embedded Human normal lung tissue and lung adenocarcinoma tissue using anti-MUC1 mouse monoclonal antibody. (UM800008; heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.0, 120C for 3min)
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Immunohistochemical staining of paraffin-embedded Human normal pancreas tissue and pancreatic cancer tissue using anti-MUC1 mouse monoclonal antibody. (UM800008; heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.0, 120C for 3min)
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Immunohistochemical staining of paraffin-embedded Human normal bladder tissue and bladder cancer tissue using anti-MUC1 mouse monoclonal antibody. (UM800008; heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.0, 120C for 3min)
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Immunohistochemical staining of paraffin-embedded human stomach carcinoma using anti-MUC1 (EMA) mouse monoclonal antibody at 1:200 dilution of1mg/mL using Polink2 Broad HRP DAB for detection. UM800008 requires heat-induced epitope retrieval with Accel pH8.7 at 110C for 3 min using pressure chamber/cooker. The image is a composite of 3 tumors which show strong membranous and cytoplasmic staining in >75 % tumor cells.
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Immunohistochemical staining of paraffin-embedded human ovarian carcinoma using anti-MUC1 (EMA) mouse monoclonal antibody at 1:200 dilution of 1mg/mL using Polink2 Broad HRP DAB for detection. UM800008 requires heat-induced epitope retrieval with Accel pH8.7 at 110C for 3 min using pressure chamber/cooker. The image is a composite of 3 tumors which show strong membranous and weak cytoplasmic staining in >75 % tumor cells.
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Immunohistochemical staining of paraffin-embedded human colon cancer using anti-MUC1(EMA) mouse monoclonal antibody at 1:200 dilution of 1mg/mL using Polink2 Broad HRP DAB for detection. UM800008 requires heat-induced epitope retrieval with Accel pH8.7 at 110C for 3 min using pressure chamber/cooker. The image is a composite of 3 tumors which show strong membranous and secreted protein however >75 % tumor cells are negative for cytoplasmic staining.
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Immunofluorescent staining of MCF-7 cells using anti-MUC1/EMA mouse monoclonal antibody (UM800008, green, 1:100). Actin filaments were labeled with Alexa Fluor® 594 Phalloidin (red), and nuclear with DAPI (blue).
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OriGene overexpression protein microarray chip was immunostained with UltraMAB anti-MUC1 mouse monoclonal antibody (Clone UMAB37). The positive reactive proteins are highlighted with two red arrows in the enlarged subarray. All the positive controls spotted in this subarray are also labeled for clarification. These data show that UltraMAB anti-MUC1 (Clone UMAB57 ) very specifically recognizes MUC1 antigen on OriGene protein microarray chip.
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