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UltraMAB

IDO1 UltraMAB Antibody, Clone Clone UMAB126

UltraMAB™ Antibodies - Validated with 10K Protein Chip

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Specifications Citations (1) Customer Reviews Product Documents
SKU Description Datasheet Price Availability*  
UM500091
  • IDO1 mouse monoclonal antibody,clone UMAB126, 100 ul
$468 In Stock Add to Shopping Cart
UM570091
  • IDO1 mouse monoclonal antibody,clone UMAB126, 30 ul
$120 In Stock Add to Shopping Cart
CE IVD Logo CE marked antibody of this clone also available.
WB(2)
Data Img
IHC(6)
Data Img
IF(1)
Data Img
10K-CHIP(1)
Data Img
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OriGene Data

ImmunogenFull length human recombinant protein of human IDO1(NP_002155) produced in HEK293T cell.
Clone NameClone Clone UMAB126 IsotypeIgG1
Species ReactivityHuman Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IHC, IF, 10K-CHIP Suggested Dilutions IHC 1:100~200,
BufferPBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens indoleamine 2,3-dioxygenase 1 (IDO1)
Alternative NameIDO; IDO-1; INDO
Database LinkNP_002155
FunctionThis gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011].
Related Pathway

* Shipping is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot of human tissue lysates (15ug) from 10 different tissues (1: Testis, 2: Omentum, 3: Uterus, 4: Breast, 5: Brain, 6: Thyroid, 7: Colon, 8: Spleen 9: Liver, 10: Ovary). Diluation: 1:500.
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Western blot of mouse tissue lysates (20ug) from Brian. Primary antibody diluation: 1:500. Secondary antibody dilution: Mouse TrueBlot® Ultra (1:1000).
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Immunohistochemical staining of paraffin-embedded Carcinoma of Human lung tissue using anti-IDO1 mouse monoclonal antibody. (UM500091; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min)
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Immunohistochemical staining of paraffin-embedded Human lymph node tissue using anti-IDO1 mouse monoclonal antibody. (UM500091; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min)
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Immunohistochemical staining of paraffin-embedded Human tonsil using anti-IDO1 mouse monoclonal antibody. (UM500091; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min)
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Immunohistochemical staining of paraffin-embedded human placenta using anti-IDO1 clone UMAB126 mouse monoclonal antibody at 1:200 dilution of 1.0 mg/mL using Polink2 Broad HRP DAB for detection. UM500091 requires HIER with with citrate pH6.0 at 110C for 3 min using pressure chamber/cooker. The placenta shows strong membrane and cytoplasmic in the endothelial cells.
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Immunohistochemical staining of paraffin-embedded human tonsil using anti-IDO1 clone UMAB126 mouse monoclonal antibody at 1:200 dilution of 1.0 mg/mL using Polink2 Broad HRP DAB for detection. UM500091 requires HIER with with citrate pH6.0 at 110C for 3 min using pressure chamber/cooker. The tonsil shows strong membrane and cytoplasmic in the germinal center and rare strong nuclear, membrane, and cytoplasmic staining in the non germinal centers.
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Immunohistochemical staining of paraffin-embedded human spleen using anti-IDO1 clone UMAB126 mouse monoclonal antibody at 1:200 dilution of 1.0 mg/mL using Polink2 Broad HRP DAB for detection. UM500091 requires HIER with with citrate pH6.0 at 110C for 3 min using pressure chamber/cooker. The spleen shows very few cells staining in the red pulp with strong nuclear, membrane, and cytoplasmic staining.
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Immunofluorescent staining of MCF-7 cells using anti-IDO1 mouse monoclonal antibody (UM500091, green, 1:100). Actin filaments were labeled with Alexa Fluor® 594 Phalloidin (red), and nuclear with DAPI (blue).
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OriGene overexpression protein microarray chip was immunostained with UltraMAB anti-IDO1 mouse monoclonal antibody (UM500091). The positive reactive proteins are highlighted with two red arrows in the enlarged subarray. All the positive controls spotted in this subarray are also labeled for clarification.
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