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UltraMAB

L1CAM UltraMAB Antibody, Clone UMAB48

UltraMAB™ Antibodies - Validated with 10K Protein Chip

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Specifications Citations Customer Reviews Product Documents
SKU Description Datasheet Price Availability*  
UM500044
  • L1CAM mouse monoclonal antibody, clone UMAB48, 100 ul
$468 In Stock Add to Shopping Cart
UM570044
  • L1CAM mouse monoclonal antibody, clone UMAB48, 30 ul
$120 In Stock Add to Shopping Cart
IHC(7)
Data Img
IF(1)
Data Img
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Also for L1CAM (NM_000425)
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OriGene Data

ImmunogenFull length human recombinant protein of human L1CAM (NP_000416) produced in HEK293T cell.
Clone NameClone UMAB48 IsotypeIgG1
Species ReactivityHuman Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *IHC, IF Suggested Dilutions IHC 1:100,
BufferPBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens L1 cell adhesion molecule (L1CAM), transcript variant 1
Alternative NameCAML1; CD171; HSAS; HSAS1; MASA; MIC5; N-CAM-L1; N-CAML1; NCAM-L1; S10; SPG1
Database LinkNP_000416
FunctionThe protein encoded by this gene is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause three X-linked neurological syndromes known by the acronym CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of a neuron-specific exon is thought to be functionally relevant. [provided by RefSeq, Jul 2008].
Related Pathway

* Shipping is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Immunohistochemical staining of paraffin-embedded Human adult brain tissue using anti-L1CAM mouse monoclonal antibody. (UM500044; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min)
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Immunohistochemical staining of paraffin-embedded Human embryonic cerebellum using anti-L1CAM mouse monoclonal antibody. (UM500044; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min)
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Immunohistochemical staining of paraffin-embedded human pituitary using anti-L1CAM clone UMAB48 mouse monoclonal antibody (UM500044) at 1:200 with Polink2 Broad HRP DAB detection kit; heat-induced epitope retrieval with GBI ACCEL HIER buffer using pressure chamber for 3 minutes at 110C. Image shows only a subset of cells with positive cytoplasmic and membraneous stain.
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Immunohistochemical staining of paraffin-embedded human colon cancer using anti-L1CAM clone UMAB48 mouse monoclonal antibody (UM500044) at 1:200 with Polink2 Broad HRP DAB detection kit; heat-induced epitope retrieval with GBI ACCEL HIER buffer using pressure chamber for 3 minutes at 110C. Image shows tumor cells with positive cytoplasmic and membraneous stain.
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Immunohistochemical staining of paraffin-embedded human melanoma using anti-L1CAM clone UMAB48 mouse monoclonal antibody (UM500044) at 1:200 with Polink2 Broad HRP DAB detection kit; heat-induced epitope retrieval with GBI ACCEL HIER buffer using pressure chamber for 3 minutes at 110C. Image shows strong positive membraneous and cytoplasmic staining in the tumor cells.
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Immunohistochemical staining of paraffin-embedded human brain using anti-L1CAM clone UMAB48 mouse monoclonal antibody (UM500044) at 1:200 with Polink2 Broad HRP DAB detection kit; heat-induced epitope retrieval with GBI ACCEL HIER buffer using pressure chamber for 3 minutes at 110C. Image shows positive cytoplasmic and membraneous stain granular layer and molecular layer.
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Immunohistochemical staining of paraffin-embedded human ovarian carcinoma using anti-L1CAM clone UMAB48 mouse monoclonal antibody (UM500044) at 1:200 with Polink2 Broad HRP DAB detection kit; heat-induced epitope retrieval with GBI ACCEL HIER buffer using pressure chamber for 3 minutes at 110C. Image shows positive cytoplasmic and membraneous stain in a subset of the tumor cells.
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Confocal immunofluoresce image of primary rat neurons labeled with anti-L1CAM mouse monoclonal antibody (UM500044, green, 1:50). Actin filaments were labeled with TRICT-Phalloidin (red), and nuclear with DAPI (blue). Scale bar, 20µm.
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