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UltraMAB

P53 UltraMAB Antibody, Clone UMAB55

UltraMAB™ Antibodies - Validated with 10K Protein Chip

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Specifications Citations Related Products Product Documents
SKU Description Datasheet Price Availability*  
UM500049
  • Purified P53 (TP53) mouse monoclonal antibody, clone UMAB55, 100 ul
468 In Stock Add to Shopping Cart
UM570049
  • TP53 mouse monoclonal antibody, clone UMAB55, 30 ul
$120 In Stock Add to Shopping Cart
WB(1)
IHC(4)
IF(2)
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Also for P53 (NM_000546)
cDNA Clone shRNA/siRNA Lysate Protein Antibody
Gene NameHomo sapiens tumor protein p53 (TP53), transcript variant 1
SynonymsBCC7; LFS1; P53; TRP53
ImmunogenFull length human recombinant protein of human TP53 (NP_000537) produced in HEK293T cell.
BufferPBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Clone NameClone UMAB55 IsotypeIgG1
Species ReactivityHuman Concentration0.5~1.0 mg/ml (Lot Dependent)
Purification Purified from mouse ascites fluids by affinity chromatography (Protein A or G Sepharose)
Guaranteed Application *WB, IHC, IF Suggested Dilutions IHC 1:100,
BackgroundThe protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. [provided by RefSeq, Jul 2008].

* Shipping is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western Blot analysis of extracts (35µg) from 11 different cell lines by using anti-TP53 monoclonal antibody (Clone UMAB55)
IHC Image
Immunohistochemical staining of paraffin-embedded Human normal colon tissue and colonrectal cancer tissue using anti-TP53 mouse monoclonal antibody. (UM500049)
IHC Image
Immunohistochemical staining of paraffin-embedded Human normal lung tissue and lung adenocarcinoma tissue using anti-TP53 mouse monoclonal antibody. (UM500049)
IHC Image
Immunohistochemical staining of paraffin-embedded Human normal ovary tissue and ovary cancer tissue using anti-TP53 mouse monoclonal antibody. (UM500049)
IHC Image
Immunohistochemical staining of paraffin-embedded Human normal breast tissue and breast adenocarcinoma tissue using anti-TP53 mouse monoclonal antibody. (UM500049)
IF Image
Immunofluorescent staining of COS7 cells using TP53 mouse monoclonal antibody (UM500049, green). Actin filaments were labeled with TRITC-phalloidin (red), and nuclear with DAPI (blue). The three-color overlay image is located at the bottom-right corner.
IF Image
Immunofluorescent staining of HT-29 cells using TP53 mouse monoclonal antibody (UM500049, green). Actin filaments were labeled with TRITC-phalloidin (red), and nuclear with DAPI (blue). The three-color overlay image is located at the bottom-right corner.

 

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