UltraMAB™ Antibodies - Validated with 10K Protein Chip
Immunohistochemical staining of paraffin-embedded Human embryonic brain cortex tissue using anti-L1CAM mouse monoclonal antibody. (UM500043)
Immunohistochemical staining of paraffin-embedded Human embryonic cerebellum using anti-L1CAM mouse monoclonal antibody. (UM500043)
OriGene overexpression protein microarray chip was immunostained with UltraMAB anti-L1CAM mouse monoclonal antibody (UM500043). The positive reactive proteins are highlighted with two red arrows in the enlarged subarray. All the positive controls spotted in this subarray are also labeled for clarification.
The protein encoded by this gene is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause three X-linked neurological syndromes known by the acronym CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of a neuron-specific exon is thought to be functionally relevant. [provided by RefSeq, Jul 2008].
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OriGene overexpression protein microarray chip was immunostained with UltraMAB anti-L1CAM mouse monoclonal antibody (UM500043). The positive reactive proteins are highlighted with two red arrows in the enlarged subarray. All the positive controls spotted in this subarray are also labeled for clarification.
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